| 摘要 |
A amino-pyridine deriv. of formula (I) or its addn. salt is prepd. by reacting a pyrimidine of formula (II) with an amine of formula (III). In the formulas, R1 is C1-6 alkyl, C3-6 cycloalkyl or phenyl C1-6 alkyl; R2 is oxo, thioxo or imino; R3 is cyano, aminocarbonyl or nitro; R4 is H or C1-4 alkyl; R5 is C2-5 alkenyl, 1-piperidinyl, C3-6 cycloalkyl, 2 or 3-indolyl, 2 or 3-thienyl, or 4-thiomorpholinyl; m is 0-2. (I) is useful as cardiotonic agents for increasing a cardiac contractility.
|
