| 摘要 |
<p>: Process for preparing 2-Phenylalkyl-3-aminoalky1-4(3H)-quinazolinone compound Disclosed are a process for preparing a 2-phenylalkyl-3-aminoalkyl-4(3H)-quinazolinone compound of Formula (1): wherein, X represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a phenoxy group, a benzyloxy group, a halogen atom or a hydroxy group; Y represents an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a benzyloxy group, a halogen atom or a nitro group; R1 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms; R2 represents an alkyl group having 1 to 5 carbon atoms or a group of Formula (2) -(CH2)? ¢wherein, Z represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or a halogen atom; c is an integer of 1 to 3; and ? is an integer of 1 to 5!; or R1 and R2 represent together with the nitrogen atom to which they are attached, a cyclic amino group of the formula: ¢wherein, A represents an alkylene group having 2 to 6 carbon atoms or a group of the formula -(CH2)2-O-(CH2)2-1; a and b are independently an integer of 1 to 3; and n and m are independently an integer of 1 to 5, or a pharmaceutically acceptable acid addition salt thereof, and said quinazolinone compound or the salt there of which is prepared according to said process. The compounds of the present invention have calcium atagonistic, vasdilative, and antihypertensive activities.</p> |
