Method for production of dimeric alkaloids.

摘要

A method for producing a dimeric alkaloid which comprises reacting catharanthine with vindoline in the presence of Fe<3><+>, and either removing or inactivating the Fe<3><+> and reacting the reaction product with a reducing agent or adding oxygen and a dicarboxylic acid or a derivative thereof to the reaction system and reacting the reaction product with a hydride source. By this method such dimeric alkaloids as vinblastine, leurocidin and 3 min ,4 min -anhydrovinblastine, which are useful as antineoplastic drugs, can be produced in high yields.