摘要 |
Antihypertensive phosphate derivatives are described having the following formula: <IMAGE> FORMULA 1 wherein n is an integer 1 or 2; m is an integer 1 or 2, and the sum of n and m must be 3; X is selected from the group consisting of C1-C24 branched or straight chain alkoxy and substituted phenoxy wherein the substituents are selected from one or more of the group consisting of C1-C20 branched or straight chain alkyl, C1-C20 branched or straight chain alkoxy, halogen, phenyl and substituted phenyl; T is selected from the group consisting of hydrogen and <IMAGE> wherein R1 is selected from the group consisting of hydrogen, C1-C4 branched or straight chain alkyl, C1-C4 branched or straight chain alkoxy and C1-C4 branched or straight chain alkylamino, Q is a bivalent radical selected from the group consisting of -(CH2)p- and -(CHR)p-, where p is an integer from 2 to 12 and the moiety -(CHR)p- represents an alkylene chain which is substituted by one or more C1-C10 alkyl groups or phenyl groups; Z is selected from the group consisting of <IMAGE> wherein R2 may be the same or different and is selected from the group consisting of hydrogen and C1-C4 branched or straight chain alkyl and q is an integer from 4 to 7.
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