CEPHALOSPORINS

摘要

There is described a process for obtaining highly pure crystalline cefuroxime axetil. The process comprises crystallising cefuroxime axetil from a solution thereof in an organic or aqueous solvent or a mixture thereof and then drying and isolating the product. Preferred solvents are alkyl acetates in admixture with ethers or aliphatic or aromatic hydrocarbons. The higher the yield from crystallisation, the closer to a 1:1 stoichiometric ratio of R:S isomers the product will contain, this being most desirable for a product having the desired properties.