发明名称 WERKWIJZE VOOR HET BEREIDEN VAN EEN FARMACEUTISCH PREPARAAT MET BLOEDDRUK VERLAGENDE EN LUTEOLYTISCHE WERKING OP BASIS VAN EEN 13-THIA-PROSTAGLANDINE-DERIVAAT ALSMEDE WERKWIJZE TER BEREIDING VAN EEN 13-THIA-PROSTAGLANDINE-DERIVAAT.
摘要 <p>13-Thiaprostanoic acid derivatives of the formula <IMAGE> wherein A is -CO- or -CHOH-, B is -CH2-CH2- or -CH=CH-, R1 is H or alkyl of 1 to 4 carbon atoms, m is a whole number from 0 to 5, n is a whole number from 0 to 3 or, when B is -CH=CH-, additionally 4, 5, 6, 7, 8 or 9, R2 is alkoxy of 1 to 4 carbon atoms, phenoxy, pyridyl, thienyl, naphthyl, phenyl substituted by F, Cl, Br, OH, OCH3 or OF3 or phenoxy substituted by F, Cl, Br, OH, OCH3, CH3 or CF3 or, when B is -CH=CH-, additionally hydrogen, phenyl or tolyl, R3 is H, methyl or ethyl, possess pharmacological activity, including blood pressure lowering activity.</p>
申请公布号 NL185145(C) 申请公布日期 1990.02.01
申请号 NL19750005481 申请日期 1975.05.09
申请人 MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG TE DARMSTADT, BONDSREPUBLIEK DUITSLAND. 发明人
分类号 C07D333/34;A61K31/557;A61K31/5575;A61P43/00;C07C;C07C67/00;C07C401/00;C07C405/00;C07D213/32;(IPC1-7):C07C321/22 主分类号 C07D333/34
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