| 摘要 |
NEW MATERIAL:The arginylanilide of formula I [A is pyroGlu group or D- Glu(OR or NR'R'') group (OR and NR'R'' are groups bonding to gamma-carboxyl group of glutamic acid; R is H, 1-8C alkyl or 3-8C cycloalkyl; R' and R'' are H, 1-7C alkyl or R' and R'' together form an N-containing 2-7C cycloalkyl); B is Gly group, Pro group, Pip group, Sar group or Ala group; X is p- nitroaniline residue or residue of its derivative]. EXAMPLE:The compound of formula II. USE:Substrate for the determination of enzymatic activity of trypsin, alpha2M-Try, etc. PREPARATION:A chromophore-forming compound such as p-nitroaniline or its derivative is bonded to arginine and successively coupled with amino acids. |
