| 摘要 |
Benzo(g)quinolines of formula (I), wherein the rings A and B are trans-fused and wherein R1 and R2 are each independently hydrogen, hydroxy or methoxy, with the proviso that R1 and R2 may not both be hydrogen; R3 is hydrogen or C1-4 alkyl; R4 is -COOH, -CH2OR5, -CH2CN, -CON(R6)R7, -CH2SR8, -NHSO2N(R9)R10 or -NHCON(R9)R10, R5 is hydrogen or C1-3 alkyl, R6 is hydrogen or C1-3 alkyl and R7 is hydrogen, C1-3 alkyl, phenyl or pyridyl, said phenyl or pyridyl being optionally substituted by halogen, methyl or methoxy or R6 and R7 together are -(CH2)4-, -(CH2)5- or -(CH2)2-O-(CH2)2-, R8 is C1-4 alkyl or pyridyl, said pyridyl being optionally substituted by halogen, methyl or methoxy, and R9 and R10 are each independently hydrogen or C1-3 alkyl or together are -(CH2)4- or -(CH2)5-, are useful for the treatment of nicotine addiction.
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