| 摘要 |
<p>A bio-reactor system (11) wherein a tubular housing (20) contains an internal circularly disposed set of blade members (50) and a central tubular filter (35) all mounted for rotation about a common horizontal axis (21) and each having independent rotational support and rotational drive mechanisms. The housing (20) blade members (50) and filter (35) preferably are driven at a constant slow speed for placing a fluid culture medium with discrete microbeads and cell cultures in a discrete spatial suspension in the housing (20). Replacement fluid medium is symmetrically input and fluid medium is symmetrically output from the housing (20) where input (65) and the output (89) are part of a loop providing a constant or intermittent flow of fluid medium in a closed loop (10).</p> |
