发明名称 |
ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF AMINOSUBSTITUEREDE SPIRO-HYDANTOIN-FORBINDELSER ELLER FARMACEUTISK ACCEPTABLE SALTE DERAF |
摘要 |
<p>A series of amino-and alkylamino-substituted spirohydantoins and pharmaceutically acceptable salts thereof useful as inhibitors of the enzyme aldose reductase and as therapeutic agents for the treatment of chronic complications associated with diabetes are disclosed. Preferred compounds include 6-chloro-8-amino-spiro[4H-2,3-dihydro-1-benzopyran-4,4'-imidazolidine] -2',5'-dione, the 6-fluoro and 8-methylamino- analogs thereof and the corresponding dihydrobenzothiopyran analogs of these compounds. The optical isomers of these compounds having the 4S-configuration are especially preferred.</p> |
申请公布号 |
DK156400(C) |
申请公布日期 |
1990.01.08 |
申请号 |
DK19810000565 |
申请日期 |
1981.02.11 |
申请人 |
PFIZER INC. |
发明人 |
SARGES, REINHARD;SCHNUR, RODNEY CAUGHREN |
分类号 |
A61K31/415;A61K31/435;A61P25/02;A61P27/02;C07D471/10;C07D491/10;C07D491/107;C07D495/10;(IPC1-7):C07D491/107 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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