| 摘要 |
NEW MATERIAL:A nucleoside analog compound having a fluorocyclopentene ring expressed by formula I (B is residue of nucleic acid bases; fluorine atom is bound to either of 2 C atoms forming an unsaturated group). EXAMPLE:(1alpha,4alpha)-(+ or -)-[2-Fluoro-4-phydroxymethyl-2-cyclopente-nyl]-5-methyl-2, 4 (1H, 3H)-pyrimidinedione. USE:Useful as an antimetabolite capable of antagonizing essential metabolites, such as malignant tumorous cells, and suppressing growth and propagation of cells and as an RNA synthesis inhibitor in medicines, agricultural chemicals, etc., such as antitumor or antiviral agent. PREPARATION:A compound expressed by formula II (R<1> is residue (B) of nucleic acid bases or functional group capable of subsequently introducing the residue of nucleic acid bases; R<2> is H r protecting group of hydroxyl group; either of X and Y is F and the other is halogen other than F, hydroxyl group, etc.) as a starting raw material is passed through eliminating reaction to afford the compound expressed by formula I. |
