发明名称 |
MANUFACTURE OF LACTOL DERIVATIVES |
摘要 |
The invention concerns a novel process for the stereospecific manufacture of novel hydroxymethyl lactols of the formula I by a one step reduction of a corresponding lactone carboxylic ester of the formula II (many of which esters are novel) using a reducing agent such as diisobutylaluminium hydride at about ambient temperature. The lactols of formula I are intermediates for the production of pharmacologically active 1,3-dioxane alkenoic acids useful in the treatment of certain cardiovascular and pulmonary medical conditions. Certain of the esters of formula II are novel and are also included in the invention. |
申请公布号 |
AU3637089(A) |
申请公布日期 |
1990.01.04 |
申请号 |
AU19890036370 |
申请日期 |
1989.06.14 |
申请人 |
IMPERIAL CHEMICAL INDUSTRIES PLC |
发明人 |
GREGORY DAVID HARRIS |
分类号 |
C07D307/30;C07C45/59;C07C47/27;C07C47/273;C07C47/277;C07C59/48;C07C205/44;C07D307/20;C07D307/33 |
主分类号 |
C07D307/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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