| 摘要 |
<p>Chromanols of formula <FORM:1057345/C2/1> where z is <FORM:1057345/C2/2> or <FORM:1057345/C2/3> and R is hydrogen, <FORM:1057345/C2/4> or <FORM:1057345/C2/5> n being an integer from 1 to 9, are obtained by reacting a quinone of formula <FORM:1057345/C2/6> with a compound containing an enediol group (e.g. ascorbic acid, isoascorbic acid, reductone, dihydroxymaleic anhydride or glucoascorbic acid) in the presence of a copper ion or an iron ion. In examples the corresponding chromanol is obtained from coenzyme Q10, 7,8-dimethoxy-2, 5 - dimethyl - 2 - (41,81,121 - trimethyltridecyl)-6-chromanol is obtained from 2, 3-dimethoxy - 5 - phytyl - 6 - methyl - 1, 4-benzoquinone (hexahydrocoenzyme Q4), a -tocopherol is obtained from 2,3,6-tri-methyl-5-phytyl-1, 4-benzoquinone, and the corresponding chromanol is obtained from vitamin K1(20), all by reaction with L-ascorbic acid in solutions containing cupric chloride, cupric acetate and ferric chloride.</p> |
