| 摘要 |
Condensed diazepinones of the general formula I …<IMAGE>… in which …<IMAGE>… is one of the divalent radicals …<IMAGE>… …<IMAGE>… …<IMAGE>… …<IMAGE>… X is a =CH- group or a nitrogen atom, A<1> and A<2> are lower alkylene radicals, R<1> and R<2> are hydrogen, lower alkyl or cycloalkyl radicals, R<3> is lower alkyl radicals, chlorine or hydrogen, R<4> is hydrogen or methyl, R<5> and R<6> are halogen, lower alkyl radicals or, where appropriate, also hydrogen, R<2> is hydrogen, chlorine or methyl, R<8> and R<9> are hydrogen or lower alkyl radicals, R<9> is additionally a halogen atom, and R<1><0> is hydrogen or methyl, and their acid addition salts and their possible enantiomers are described; processes for preparing these compounds are also described. …<??>The compounds are suitable as vagal pacemakers for the treatment of bradycardias and bradyarrhythmias; they have spasmolytic effects on peripheral organs, especially colon, bladder and bronchi. |
