| 摘要 |
A method for inhibiting blood vessel blockage in a mammal particularly after a procedure such as angioplasty, an arterial by-pass operation or an allograft transplant operation which comprises: administering to a mammal before, during and/or after procedure an effective blood vessel blockage inhibiting amount of an octapeptide having formula (I), wherein each A1 and A2, independently, is H, C1-12 alkyl, C7-10 phenylalkyl, R1CO (where R1 is C1-20 alkyl, C3-20 alkenyl, C3-20 alkinyl, phenyl, naphthyl, or C7-10 phenylalkyl), or R2OCO (where R2 is C1-10 alkyl or C7-10 phenylalkyl), provided that when one of A1 or A2 is R1CO or R2OCO, the other must be H; A3 is CH2A6 (where A6 is pentafluorophenyl, naphthyl, pyridyl, or phenyl); A4 is o-, m- or, more preferably, p-substituted X-Phe (where X is a halogen, H, NH2, NO2, OH, or C1-13 alkyl), pentafluoro-Phe, beta -Nal or Tyr; A5 is Thr, Ser, Phe, Val, alpha -aminobutyric acid, or Ile; A7 is Thr, Trp, or beta -Nal (and can be either the D- or L-isomer); and Z is NH2 or OH; or a pharmaceutically acceptable salt thereof. |
