Immunostimulating 7-deaza-7-oxa-and 7-deaza-7-thia-analogs of 8-substituted-guanine-9-(1'-beta-d-aldoglycosidyl) derivatives, compositions and methods.

摘要

An immune response-enhancing guanosine analog derivative having a structure that conforms to the formula <CHEM> wherein Z is oxygen (O) or sulfur (S); X is oxygen (O), sulfur (S) selenium (Se) or cyanimino 9NCN); and R1 is an aldoglycoside is disclosed. Also disclosed are a composition containing the guanosine analog derivative as active ingredient and a method of using the composition for immunostimulation.