| 摘要 |
NEW MATERIAL:The quinolinecarboxylic acid derivative of formula I [R<1> is H, alkyl or (substituted) phenyl; R<2> is H or alkyl; R<3> is H, halogen or alkoxy] and its salt. EXAMPLE:6-Fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl)methy l-1- piperazinyl]4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid ethyl ester. USE:It has antibacterial activity and is useful as a remedy for various infectious diseases. It exhibits the effect against Gram-positive bacteria and Gram-negative bacteria and is easily absorbed by oral administration. It has low toxicity and is effective for the remedy of systemic, urinary and biliary infections. PREPARATION:The compound of formula I can be produced according to the reaction formula by reacting a compound of formula II with a compound of formula III in a solvent in the presence of a base at -5 deg.C - room temperature. |
