| 摘要 |
<p>Atrial peptides comprising the amino acid sequence as follows: <IMAGE> wherein R1 is hydrogen, Ser, Cit, SerSer, Arg, Carbamoyl Ser, Guanido-Ser-Ser, Amcca, Guanido-Amcca, Lys, ArgArg, Ser-Arg, Ser-Lys, Acetyl-Ser-Ser, D-Ser-Ser, Ser-D-Ser, Guanido-Aocta, Aunda, Aocta, Ahexa, HSer, Apenta, Papaa, Abuta, Mamba, Orn, D-Orn or Acetyl-apenta, Acetyl-Ahexa, Guanido; R2 is Cys, D-Cys or Pen; R3 is L-Phe, D-Ala, L-Ala, D-Val, D-Cha, Sar, D-Phg, Aib, beta -Ala or Gly; R4 is Phe, Trp, D-Tic, L-Tic, N-MePhe, D-Ala, Tyr, 2-Thi, DimeDOPA or DOPA; R5 is Gly-Gly, Ala-Gly, D-Ala-Gly, Gly-Ala, Amcca, Mapaa or Papaa; R6 is Arg, D-Arg or Cit; R7 is Ile, Leu, D-Leu or Met; R8 is Asp, Asn, beta -methylAsp, cycloAsp, Gly or Ser; R9 is Arg, D-Arg or Ala; R10 is Ile, Leu or Phe; R11 is Cys, D-Cys, HCys, Cys-4-thiomethylproline, or trans-4-thiomethylproline; R12 is absent, Phe, D-Ala-Phe, D-Phe, Cha, Pro, D-Pro, 2-Thi, Aic, D-Tic, trans-4-FPro, L-Tic, Leu, Ile or beta -NAl; R13 is OH, Arg, Arg-NH2, D-Arg, Gln, Lys, HomoArg, or Gly; or pharmaceutically acceptable salts, esters or amides thereof.</p> |
