发明名称 |
METHOD OF PREPARING A CHLORINATED, BROMINATED, RADIOBROMINATED, IODINATED AND/OR RADIOIODINATED, AROMATIC OR HETEROAROMATIC COMPOUND, AS WELL AS A KIT FOR PREPARING A DIAGNOSTIC COMPOSITION ON THE BASIS OF THIS COMPOUND |
摘要 |
<p>The invention relates to a method of preparing a chlorinated, brominated, radiobrominated, iodinated and/or radio-iodinated aromatic or heteroaromatic compound, in which the (hetero)aromatic nucleus optionally comprises one or more additional substituents, by reacting the corresponding halogenated or diazonium-substituted compound in the presence of a water-soluble acid and of copper ions as a catalyst with a likewise water-soluble chloride, bromide radiobromide, iodide or radio-iodide, in which the reaction is carried out in the presence of one or more reduction agents, which are stable in acid medium, in a quantity exceeding the quantity of catalyst. The invention also relates to a composition suitable for diagnostic examination and to a kit for the preparation thereof. The invention further relates to a method and an equipment for the preparation of said composition.</p> |
申请公布号 |
EP0165630(B1) |
申请公布日期 |
1989.10.18 |
申请号 |
EP19850200798 |
申请日期 |
1985.05.20 |
申请人 |
MALLINCKRODT, INC.(A MISSOURI CORPORATION) |
发明人 |
MERTENS, JOHN |
分类号 |
A61J3/00;A61K49/04;A61K51/00;A61K51/04;A61K51/12;A61M5/178;A61M5/31;C07B39/00;C07B59/00;C07B61/00;C07C45/63;C07C51/363;C07C57/58;C07C63/70;C07C209/74;C07C211/29;C07F1/08 |
主分类号 |
A61J3/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|