Occlusive body for administering a physiologically active substance.

摘要

An occlusive body such as a patch, pad or bandage is provided which incorporates a reservoir (5) containing a physiologically active substance, the reservoir incorporating a membrane (3) permeable to the active substance and either the membrane being hydrophilic and the reservoir contents being hydrophobic or vice versa. The reservoir also contains a filler material such as methyl cellulose which immobilises the reservoir contents e.g. by forming a gel. The dosage rate of the active substance through the membrane when the latter is applied to the skin of a subject is substantially constant until much of the dose has been delivered from the reservoir.