Process for the preparation of cyclopentanoids and novel intermediates produced thereby

摘要

Cyclopentanoids (I) of the formula: <IMAGE> (I) including stereoisomers are described along with a process for the preparation of I. In particular the preparation of prostanoids of the formula: <IMAGE> wherein R1 is a alkyl group containing 1 to 8 carbon atoms and R2CO2R3 is an alkenyl ester group, R2 contains 2 to 6 carbon atoms and R3 is a lower alkyl group containing 1 to 6 carbon atoms is described. A particular prostaglandin prepared by the process is PGE2. The prostanoids have been demonstrated to have pharmacological activity in animals and humans. Novel intermediates of (I) are also described.