| 摘要 |
PURPOSE:To obtain stable liposome with a slight leakage of including drug, by using polyethylene glycol derivative and lipid. CONSTITUTION:2,4-bis(polyethylene glycol)-6-amino-S-triazine derivative expressed by the formula (n is 6-200; R1 and R2 is H, alkyl, alkylcarbonyl or alkylsulfonyl; R3 and R4 is H or methyl; with the proviso that amino group is not amino residue included in enzyme or protein) and phospholipid (e.g., egg yolk lecithin) are prepared by conventional liposome forming method to afford the aimed substance. Active PEG2 made in SEIKAGAKU KOGYO KK is reacted with amine in toluene solvent in the presence of Na2CO3 at room temperature to afford the compound expressed by the formula. |
