Naphthyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them

摘要

The present invention relates to new naphthyl derivatives of general formula <IMAGE> (I) wherein N represents the number 1 or 2, A represents a -CH2-, -CO-, -CH2CH2-, -CH=CH-, <IMAGE> while the atom marked with an x is linked to the phenyl nucleus, E represents a straight chained alkylene group optionally substituted by an alkyl group, G represents a straight chained alkylene group optionally substituted by an alkyl group, L represents a bond or an oxygen atom, if G represents a straight chained alkylene group with 2 to 5 carbon atoms optionally substituted by an alkyl group, R1 and R2, which may be identical or different, represent alkyl or alkoxy groups or R1 and R2 together represent an alkylenedioxy group, R3 represents a hydrogen atom, or an alkyl or an allyl group, R4, R5 and R6, which may be identical or different, represent hydrogen atoms, alkyl or alkoxy groups, the enantiomers and the acid addition salts thereof, which have valuable pharmacological properties, particularly a heart rate lowering activity. The new compounds may be prepared using methods known per se.