SUBSTITUTED PHENYLTHIOUREA, PHENYLISOTHIOUREA, PHENYLCARBODIIMIDE, SALTS THEREOF, MANUFACTURE AND INTERMEDIATES THEREFOR

摘要

A medical article having a layered antithrombogenic surface is useful as a polymeric implant. The article comprises a polymeric substrate coated with chitosan to which is appended an antithrombotic agent. A process for rendering the surface of a polymer antithrombogenic is disclosed.