IMIDAZOLE DERIVATIVES HAVING ANTIMYCOTIC AND ANTIBACTERIAL ACTIVITIES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Compounds of formula I (I) wherein R is a phenyl group; a phenyl group mono- or di-substituted by halogen atoms, methyl, methoxy, nitro, or trifluoromethyl group; or a 2-, 3- or 4-pyridyl group; and pharmaceutically acceptable acid addition salts thereof. Compounds I are prepared by reacting N-substituted piperazines with 1-(2',4'-dichloro-benzoylmetyl)-imidazole, optionally reducing thereafter the resulting enamines. Compounds I have antimycotic and antibacterial activities, higher than those of known comparison drugs.