SALICYCLIC ACID DERIVATIVES AS PROTEASE INHIBITORS

摘要

This invention relates to methods of preventing or reducing the degradation of elastin and other proteins and thereby preventing or retarding the disease states caused by said degradation by administering compounds of the formula: wherein R1 is: a) hydrogen; or b) alkyl of 1 to 6 carbon atoms, inclusive; wherein R2 is: a) hydroxy; or b) alkoxy of 1 to 6 carbon atoms, inclusive; wherein R3 is: a) -C(O)R4; b) -CH(OH)R4; c) -CH2R4; or d) -CH=CHR4; wherein R4 is alkyl of 13 to 25 carbon atoms inclusive, or a pharmacologically acceptable salt thereof.