| 摘要 |
<p>Hypoglycemic thiazolidine-2,4-dione derivatives of formula (I), wherein the dotted line represents a bond or no bond; A and B are each independently CH or N, with the proviso that when A or B is N, the other is CH; X is S, SO, SO2, CH2, CHOH or CO; n is 0 or 1; Y is CHR?1 or NR2¿, with the proviso that when n is 1 and Y is NR2, X is SO¿2? or CO; Z is CHR?3, CH¿2CH2, CH=CH, (a), OCH2, SCH2, SOCH2 or SO2CH2; R, R?1, R2 and R3¿ are each independently hydrogen or methyl; and X?1 and X2¿ are each independently hydrogen, methyl, trifluoromethyl, phenyl, benzyl, hydroxy, methoxy, phenoxy, benzyloxy, bromo, chloro or fluoro; a pharmaceutically-acceptable cationic salt thereof, or a pharmaceutically-acceptable acid addition salt thereof when A or B is N.</p> |
