PROCESS FOR PREPARING THIAZOLE COMPOUNDS

摘要

Title compds. (I)[R1=amino, acylamino, etc.; R2=H, lower alkyl, aryl; R3=H, NO2, amino, acylamino, OH, lower alkoxy; A=lower alkylene; Q=H, halo were prepd. Thus, a mixt. contg. 480mg 2-acetylamino-4- chloromethyl thiazole, 500mg 3-(4-piperidyl) indole, 310mg sodium hydrogen carbonate, 5ml N,N-dimethyl formamide, and 7ml THF was refluxed 1hr and 40min to give 270mg 2acetylamino-4-[4-(3-indollyl)- piperidinomethyl thiazole.