New optically active intermediates and processes thereto are provided for use in synthesizing therapeutically active prostaglandins of the formula: <IMAGE> XVI wherein R1 is hydrogen or lower alkyl; from a compound of the formula: <IMAGE> I wherein R1 is as above and R2 is hydrogen or a carboxy blocking group convertible to an acid by hydrolysis.
申请公布号
US4866205(A)
申请公布日期
1989.09.12
申请号
US19880218427
申请日期
1988.07.11
申请人
HOFFMAN-LA ROCHE INC.;HOFFMAN-LA ROCHE INC.
发明人
COFFEN, DAVID L.;HOLLAND, GEORGE W.;MANDEVILLE, W. HARRY;ROSEN, PERRY;WONG, FREDERICK