| 摘要 |
PURPOSE:To efficiently and readily extract a carboxylic acid derivative, by treating an aqueous medium containing both the carboxylic acid derivative and biological ingredients with an organic solvent of a specified concentration at a specified pH to flocculate and remove the biological ingredients. CONSTITUTION:Firstly, the pH value of an aqueous medium containing (A) a carboxylic acid derivative of formula I (R1 is alkyl, aralkyl or aryl group; R2 and R3 are each H or alkyl group; n is 1 or 2) produced by e.g., biological asymmetric hydrolysis of a racemic carboxylic ester and (B) such biological ingredients as bacteria decomposed product, protein, nucleic acid or the like is adjusted to <=5. Thence, said aqueous medium is incorporated with an organic solvent such as a halogenated hydrocarbon, alcohol or ester so that the concentration is at or below the saturated solubility for said aqueous medium to flocculate the biological ingredients. Said biological ingredients are then removed, and the resultant aqueous medium is spiked with an organic solvent, thus extracting the objective carboxylic acid derivative. |
