摘要 |
<p>Compounds are disclosed of formula (I) <CHEM> wherein Ra, Rb, Rc and Rd represent hydrogen atoms or Ra and Rc together form a bond and Rb and Rd together form -CH=CH-CH=CH-; - @@ represents a 5-membered (optionally containing an oxygen atom adjacent to the nitrogen) or a 6-membered ring, which ring optionally contains one unit of unsaturation and which is unsubstituted or substituted by hydroxy, hydroxymethyl, oxo, optionally substituted methylidene, -COR1 (where R1 is C1-6 alkyl, -OR2 or -NHR2, and R2 is hydrogen, C1-6 alkyl, aryl or ar(C1-6)alkyl) or =NOR3 (where R3 is C1-6 alkyl); X represents a direct bond, -CH2- or -CH2O-; Ar represents a substituted phenyl moiety (provided that when -N does not contain an oxygen atom and is unsubstituted, Ar contains more than one unsaturated ring); and physiologically acceptable salts and solvates thereof. The compounds are indicated as useful for the treatment of pain and cerebral ischaemia. Processes and intermediates for their preparation and pharmaceutical compositions containing them are also disclosed.</p> |