| 摘要 |
<p>Tumor necrosis factor alpha (TNF-alpha) and tumor necrosis factor beta have now been shown to synergistically enhance the oncolytic function of human interleukin-2 (IL-2) activated lymphocytes (LAK). The presence of TNF-alpha or beta during activation consistently augments the LAK cytotoxic function two to four fold above that observed solely with IL-2. Furthermore, IL-2/TNF generated LAK, cultured with a ten-fold lower IL-2 concentration, demonstrate cytotoxic function equivalent to that observed with a ten-fold greater IL-2 alone stimulation, culture of lymphocytes with TNF alone is not sufficient for the generation of detectable LAK function. This novel synergy can be exploited under conditions in which the concentration of IL-2 would otherwise be limiting.</p> |
