发明名称 Dihydropyridine spray, process for its preparation and its pharmaceutical use
摘要 A sprayable liquid formulation comprising, per 100 ml of the formulation, (a) 0.2 to 5 grams of a dihydropyridine of the formula <IMAGE> in which R1 and R2 each independently is alkyl with 1 to 10 carbon atoms optionally substituted by alkoxy with 1 to 3 carbon atoms, trifluoromethyl, halogen or N-methyl-N-benzylamino, R3 is alkyl with 1 to 4 carbon atoms, cyano or hydroxymethyl, and X is a nitro group, one or two chlorine groups or the ring member =N-O-N=, (b) 10 to 40 grams of polyethylene glycol with an average molecular weight of 200 to 600, (c) 25 to 60 grams of ethyl alcohol, and (d) 3 to 15 grams of polyvinylpyrrolidine with an average molecular weight of 12000 to 30000.
申请公布号 US4857312(A) 申请公布日期 1989.08.15
申请号 US19880169566 申请日期 1988.03.17
申请人 BAYER AKTIENGESELLSCHAFT 发明人 HEGASY, AHMED;RAEMSCH, KLAUS-DIETER
分类号 A61K31/455;A61K9/00;A61K9/12;A61K31/44;C07D211/90;C09K3/30 主分类号 A61K31/455
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