发明名称 |
Stable pharmaceutical composition |
摘要 |
An injectable, aqueous pharmaceutical composition for the treatment of cardiac conditions comprising an effective amount of methyl 3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate hydrochloride (esmolol) for treating such a cardiac condition, said composition comprising about 1 mg to 250 mg of esmolol per milliliter of said injectable pharmaceutical composition; 0.01 to 0.02M buffer; said composition having a pH range of 4.5 to 5.5, the esmolol degrading in aqueous solution to produce 3-[4-(3-propionic acid)phenoxy]-1-isopropylamino-2-propanol hydrochloride, said 3-[4-(3-propionic acid)-phenoxyl]-1-isopropylamino-2-propanol hydrochloride having a pK in the pH range of said composition to thereby act as a secondary buffer to increase the buffer capacity and minimize the change in pH as degradation occurs, whereby the stability of esmolol in an aqueous composition is enhanced.
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申请公布号 |
US4857552(A) |
申请公布日期 |
1989.08.15 |
申请号 |
US19880203836 |
申请日期 |
1988.06.08 |
申请人 |
E. I. DU PONT DE NEMOURS AND CO. |
发明人 |
ROSENBERG, LEONARD S.;BLACK, CHERYL;SPEICHER, EARL R.;WAGENKNECHT, DIETMAR |
分类号 |
A61K9/00;A61K9/08;A61K31/19;A61K31/195;A61K31/215;A61K31/22;A61K47/12;A61P9/12;A61P25/02 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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