发明名称 |
1,5-BENZOXATHIEPIN DERIVATIVES, THEIR PRODUCTION AND USE |
摘要 |
<p>of The Disclosure Novel 1,5-benzoxathiepin derivatives of the formula: (IV) ¢wherein R1 and R2 are independently hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy; X is hydrogen, optionally substituted lower al? ally substituted aryl or a carboxyl group which may be esterified or amidated; Y is < IMG > or < IMG > (wherein R5 is hydrogen, acyl or optionally substituted carbamoyl); m is an integer of 0 to 2; n is an integer of 1 to 6; and W' is halogen or sulfonyloxy! and salts thereof are useful as intermediates for producing related compound which exhibit serotonin S2 receptor blocking activity, calcium antagonism, actions to relieve cerebral vasospasm and to improve renal circulation and diuretic and antithrombotic activities.</p> |
申请公布号 |
CA1258463(A) |
申请公布日期 |
1989.08.15 |
申请号 |
CA19880575740 |
申请日期 |
1988.08.25 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
SUGIHARA, HIROSADA;HIRATA, MINORU |
分类号 |
A61K31/385;A61K31/39;A61K31/495;A61P11/00;C07D327/02;C07D411/06;C07D411/12;(IPC1-7):C07D327/02;C07D411/02 |
主分类号 |
A61K31/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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