Isoquinolinones.

摘要

Therapeutically useful isoquinolinone derivatives of the formula A-X-R<3>, wherein A represents a group of the formula: <CHEM> wherein R<1> and R<2> represents cycloalkyl, alkyl, alkenyl or alkynyl optionally substituted by halogen or cycloalkyl, or represents optionally substituted aryl or heteroaryl, R<4> represents hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group R<6>O- wherein R<6> represents alkyl, aryl or arylalkyl, X represents ethylene or vinylene, R<3> represents a group of the formula:- -Y<1>-CH2-CH(OH)-CH2-COOR<5> wherein Y<1> represents carbonyl, hydroxymethylene or -C(OR)2- wherein R represents alkyl or the two R symbols together represent alkylene and R<5> represents hydrogen or optionally substituted alkyl or R<3> represents a lactol or lactone ring, and pharmaceutically acceptable salts thereof, processes for their preparation and compositions containing them are described.