| 摘要 |
Prodn. of 4-(6-methoxy- 2-naphthyl)- 2-butanone (I) is effected by converting a 2-halo- 6-methoxynaphthalene of formula (II) to an organometallic deriv., reacting this with an opt. protected 2-butanone deriv of formula QCH2CH2CXCH3 (III) and removing any protecting gp. In the formulae, Y=halogen; Q=a leaving gp; CX=opt. protected CO. Pref Q=halogen, 1-4C alkanoyloxy, tosyloxy, nesyloxy, triflate, phosphonium, sulphonium or trialkylammonium; X=diethoxy, dimethylthio, ethylenedioxy, propylenedioxy or ethylenedithio.
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