摘要 |
<p>Bis-platinum complexes of formula (I), wherein A is a disubstituted 1,4-anthracenedione; X, X' are ligands selected from the group consisting of Cl, Br, OH, CH3SOCH3.OH or CH3SOCH3.Hal or, taken together, form the anion of a dicarboxylic acid; n is zero, 0.5 or an integer from 1 to 5; Solv is a solvent of crystallization; Ra is hydrogen, alkyl optionally substituted by hydroxy groups and/or interrupted by oxygen atoms; Rb is alkyl optionally substituted by hydroxy, alkoxy, polyalkoxy or sulphonic groups or a residue of an amino-sugar. Compounds (I) are useful as anti-tumor agents.</p> |