| 摘要 |
NEW MATERIAL:A compound expressed by formula I (A is amino acid residue; formula II is 5-6 membered saturated heterocyclic ring, occasionally containing heteroatom other than bound N atom). EXAMPLE:1-{(R)-(-)-3-(N-Carbobenzoxy-beta-alanyl)thiazolidine-4-carbonyl} pyrrolidine. USE:Useful as a remedy for amnesia and possessing inhibitory activity against prolyl endopeptidase. PREPARATION:For example, a carboxylic acid expressed by formula III (reactive functional derivative) is reacted with a cyclic amine expressed by formula IV, preferably in the presence of a condensing agent (e.g., N,N'- dicyclohexylcarbodiimide). |
