摘要 |
It has been found that the novel compounds of the formula …<CHEM>… wherein R1 is phenyl substituted with 1 to 3 lower alkoxy groups or 1 to 3 halogens, R2 is hydroxy, lower alkoxy, lower alkanoyloxy, lower cycloalkylcarbonyloxy,……-O- @-O-(C1-C5 alkyl) or -O-@(CH2) m-O-(C1-C3 a lkyl),…R3 and R4 are, independently, lower alkyl, phenyl lower alkyl or, taken together, form a piperidine or pyrrolidine ring, n is 2 to 4 and m is 1 to 2,…and pharmaceutically acceptable acid addition salts thereof have activity as calcium channel blockers and, accordingly, are useful as agents for treating ischemia and as agents for lowering blood pressure. They can be prepared by reacting a compound of the formula …<CHEM>… with a compound of the formula …<CHEM>…and optionally converting the compound thus obtained to a compound wherein R2 is other than hydroxy. |