| 摘要 |
Pyrido-benzothiazine derivatives having the following general formula: <CHEM> in which R is H or a C1-C6 alkyl or a C1-C6 fluoroalkyl, and R1 is N-alkyl-3-pyrrolidinalkylamine with C1 to C6 alkyls or <CHEM> where R2 is a C1-C6 alkyl or a C2-C6 alkenyl or an arylalkyl group, possibly substituted by halogen, hydroxy or keto-groups, both in the racemic form and in the optically active form. The invention also comprises the process for the preparation of derivatives of formula (I) starting from 2.4-difluoro-3-chloronitrobenzene. Said derivatives possess a high antibacterial acitvity as well as a high bioavailability to tissues; the invention also refers to pharmaceutical compositions containing them as active components. |
