发明名称 |
PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR ASSOCIATED PROTEINS,CLONING, EXPRESSION AND METHODS OF USE |
摘要 |
The present invention relates to nucleic acids encoding PBR-associated proteins (PAPs) and methods for use in producing PAPs and methods of using PAPs. In this study we have identified proteins (PAPs) that interact with PB R protein by a yeast two-hybrid system. We used PBR as bait to screen a mouse testis cDNA library. Five clones were isolated based on their ability to interact with PBR. These proteins may be involved in the regulation of the function of PBR, serving as an endogenous ligand or allosteric modulator of the receptor.
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申请公布号 |
CA2339328(A1) |
申请公布日期 |
2000.02.24 |
申请号 |
CA19992339328 |
申请日期 |
1999.08.11 |
申请人 |
GEORGETOWN UNIVERSITY MEDICAL CENTER |
发明人 |
PAPADOPOULOS, VASSILIOS;LI, HUA |
分类号 |
G01N33/50;A61K38/00;A61K45/00;A61P3/06;A61P25/00;A61P35/00;C07K14/705;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/02;C12P21/08;C12Q1/68;G01N33/15;G01N33/53;G01N33/566;G01N33/58;G01N33/68;(IPC1-7):C12N15/12;C07K16/18;C07K14/47 |
主分类号 |
G01N33/50 |
代理机构 |
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