发明名称 |
1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives, process for producing them and use thereof. |
摘要 |
<p>The present invention relates to novel 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime-O-sulfonic acid compounds, (I), processes for producing said compounds, intermediate compounds to produce said compounds and compositions containing said compounds with potent diuretic activity that can be used for treating and/or preventing hypertension, oedema and/or for removing ascites. <CHEM> The present invention is based on the selection of 1-acyl-7-halo-2,3-dihydro-4(1H)-quinolinone-4-oxime-O-sulfonic acid compounds, namely heterocyclic-or fused heterocyclic- carbonyl derivatives at 1 position. The compounds of the present invention containing these substituents have potent hypotensive, anti-oedematous and diuretic effect as well as an activity to remove ascites and are extremely useful for the treatment of diseases and disorders mentioned above.</p> |
申请公布号 |
EP0315115(A2) |
申请公布日期 |
1989.05.10 |
申请号 |
EP19880118167 |
申请日期 |
1988.10.31 |
申请人 |
MOCHIDA PHARMACEUTICAL CO., LTD.;HODOGAYA CHEMICAL CO., LTD. |
发明人 |
MOCHIDA, EI;UEMURA, AKIO;KATO, KAZUO;TOKUNAGA, HIROKI;HAGA, AKINORI |
分类号 |
C07D215/22;A61K31/47;A61P3/00;A61P7/10;A61P9/12;C07D215/233;C07D215/42;C07D401/06;C07D403/06;C07D405/06;C07D409/06;C07D413/06 |
主分类号 |
C07D215/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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