| 摘要 |
Compounds of the formula <CHEM> wherein R<1> is hydroxy, alkoxy of 1 to 6 carbon atoms, or NR<4>R<5>, wherein R<4> and R<5> are independently selected from hydrogen and alkyl of 1 to 6 carbon atoms; R<2> is hydrogen, hydroxy, alkanoylamino of 1 to 6 carbon atoms, morpholino, halogen, cyano, hydroxyalkyl of 1 to 6 carbon atoms, COOR<6> wherein R<6> is hydrogen or alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms or NR<7>R<8> wherein R<7> and R<8> are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, aminoalkyl of 2 to 6 carbon atoms, alkylaminoalkyl wherein each alkyl group is independently selected from alkyl groups having 2 to 6 carbon atoms, and dialkylaminoalkyl wherein each alkyl group is independently selected from alkyl groups having one to six carbon atoms; and R<3> is hydrogen, alkyl of 1 to 6 carbon atoms, phenyl or substituted phenyl wherein the phenyl group may be substituted with one or two substituents selected from the group consisting of alkyl of 1 to 6 carbon atoms, nitro, amino, halogen, (e.g., fluoro, chloro, bromo, or iodo), haloalkyl of 1 or 2 carbon atoms and up to 5 halogen atoms (e.g., fluoro, chloro, bromo or iodo), hydroxyl, or alkoxy of 1 to 6 atoms;and pharmaceutically acceptable salts thereof. The compounds have antibacterial activity. |
