发明名称 A novel synthesis of chemiluminescence labels for immuno assays.
摘要 <p>Cyclic hydrazides and methods for synthesizing them are disclosed. Specifically, chemiluminescent phenanthrene cyclic hydrazides may be manufactured by a process employing modified Diels-Alder reaction. A cyclic hydrazide of a cyclic compound may be synthesized by adding an alpha , OMEGA -acetylenedicarboxylic acid ester to an ethylene substituent of a cyclic compound to form a cyclic dicarboxylate of the cyclic compound, and reacting the cyclic dicarboxylate with hydrazine to form a chemiluminescent cyclic hydrazide. Phenanthrene cyclic hydrazides according to the present invention include 9-[N-ethyl-N-butyl] aminophenanthrene-1,2-dicarboxylic acid hydrazide and 9-(dipropane sulfonic acid)aminophenanthrene-1,2-dicarboxylic acid hydrazide.</p>
申请公布号 EP0313919(A2) 申请公布日期 1989.05.03
申请号 EP19880116906 申请日期 1988.10.12
申请人 ABBOTT LABORATORIES 发明人 CHAN, CLIFFORD MAN
分类号 C07D237/26;C07H21/00;G01N33/532;G01N33/533;G01N33/536;G01N33/58 主分类号 C07D237/26
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