SUBSTITUTED 5-HYDROXY-2,3-DIHYDROBENZOFURANS AND 6-HYDROXY-2,3-DIHYDROBENZOPYRANS AND ANALOGUES THEREOF USEFUL AS ANTI-INFLAMMATORY AGENTS

摘要

Novel substituted 5-hydroxy-2,3-dihydrobenzofurans and analogs thereof having the general formula

and pharmaceutically acceptable salts thereof are disclosed wherein m is an integer ranging from 1 to 4;
A is
(a) phenyl substituted with (R<1>)q wherein when there are more than one R<1> (q > 1) R<1> can be the same or different from each other and is
(1) hydrogen;
(2) halo;
(3) loweralkoxy;
(4) lower alkylthio;
(5) lower alkyl sulfinyl;
(6) lower alkyl sulfonyl;
(7) unsubstituted or substituted phenyl; loweralkoxy;
(8) loweralkyl
(9) loweralkenyl;
(10) lower alkanoyl;
(11) haloloweralkyl;
(12) -COOH or -COOC1-6alkyl;
(13) aryl;
(14) aryloxy;
(15) cyano;
(16) hydroxyloweralkyl;
(17) halo loweralkanoyl;
(18) heteroaryl as defined below; or
(19) loweralkanoyloxy;
q is an integer ranging from 0 to 5;
(b) unsubstituted or substituted heteroaryl selected from a group consisting of:
(1) thienyl;
(2) benzothienyl;
(3) furyl;
(4) benzofuryl;
(5) pyrryl;
(6) indolyl;
(7) thiazolyl;
(8) benzothiazolyl;
(9) thiadiazolyl;
(10) benzothiadiazolyl;
(11) quinolyl;
(12) isoquinolyl;
(13) pyridyl;
(14) pyrazinyl;
(15) tetrazolyl; or
(16) triazolyl,
the heteroaryl above being substituted with one or more of R<1>.
Those compounds are useful as anti-inflammatory agents. A Process for preparing those compounds is also disclosed.