Analgesia-effecting 5-hydroxytryptophan derivatives.

摘要

Analgesia-effecting 5-hydroxytryptophan derivatives are disclosed of the formulae:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="34" wi="80" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and
<Chemistry id="chema02" num="0002"><Image id="ia02" he="39" wi="112" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R is selected from the group consisting of C<Sub>2</Sub>-C<Sub>16</Sub> alkyl, C<Sub>3</Sub>-C<Sub>8</Sub> cycloalkyl, C<Sub>2</Sub>-C<Sub>16</Sub> alkenyl. C<Sub>2</Sub>-C<Sub>16</Sub> alkynyl, aryl containing up to 14 carbon atoms, and arylalkyl containing up to 20 carbon atoms;
<UnorderedLists id="ula01" listStyle="none"><ListItem>R' and R" are each H or methyl;</ListItem><ListItem>R<Sup>2</Sup> and R<Sup>2a</Sup> are each H or R, as defined above;</ListItem><ListItem>R<Sup>3</Sup> and R<Sup>3a</Sup> are each H or alkyl containing from 1 to 4 carbons;</ListItem><ListItem>R<Sup>4</Sup> and R<Sup>4a</Sup> are each H or alkyl containing from 1 to 4 carbons;</ListItem><ListItem>and their non-toxic, pharmacologically acceptable acid addition salts.</ListItem></UnorderedLists>