| 摘要 |
NEW MATERIAL:The compound of formula I (R1 is H or methyl; n is number of double bonds having trans configuration and is 1 or 2; X is group of formula II, formula III, etc.). EXAMPLE:2-[5-(4-Hydroxy-3-methoxyphenyl)-2,4-pentadienoylamino]thiazol ine. USE:A 5-lipoxygenase inhibitor. Effective against allergic asthma, rhinitis, nephritis, hepatitis, rheumatism and gastric ulcer. PREPARATION:The compound of formula I can be produced by the condensation reaction and deprotection reaction of a carboxylic acid derivative of formula IV (Rm is 3,4-dimethoxymethyloxy, etc.) with an amine derivative of formula V, VI, VII or VIII (R2 is H or 1-10C alkyl). |
