发明名称 |
Amphotericin B/cholesterol sulfate composition |
摘要 |
An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 1:4. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes predominantly between about 100-400 nm. The composition formed at a molar ratio of about 1:1 amphotericin B:cholesterol sulfate ahs stable particle sizes in an aqueous suspension over a several-day storage period. The composition is significantly less toxic and more effective in treating fungal infection than prior amphotericin B formulations.
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申请公布号 |
US4822777(A) |
申请公布日期 |
1989.04.18 |
申请号 |
US19870019575 |
申请日期 |
1987.02.27 |
申请人 |
LIPOSOME TECHNOLOGY, INC. |
发明人 |
ABRA, ROBERT;SZOKA FRANCIS C |
分类号 |
A61K9/00;A61K;A61K9/10;A61K9/107;A61K9/51;A61K31/575;A61K31/70;A61K47/28;A61P31/04;C07H7/06;(IPC1-7):A61K31/70 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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