PTERIDINES, PROCESSES FOR PREPARING THEM AND THEIR USE AS INTERMEDIATE PRODUCTS OR AS PHARMACEUTICAL COMPOSITIONS

摘要

Pteridine Derivatives New pteridines of formula (I) (wherein R2 represents a piperazino or N-formyl-piperazino group, R4 represents a dialkylamino, phenylalkylamino, N-alkyl-phenylalkylamino, pyrrolidino, piperidino, morpholino, thiomorpholino, 1-oxidothiomorpholino, thiazolidino or 1-oxidothiazolidino group, R6 represents a hydrogen atom or an alkyl or phenyl group, and R7 represents an alkylamino, dialkylamino, phenylalkylamino, N-alkyl-phenylalkylamino, piperidino, morpholino, thiomorpholino, 1-oxidothiomorpholino or piperazino group; wherein each alkyl moiety in groups R4, R6 and R7 contains from 1 to 3 carbon atoms; wherein, where R4 contains one or two C2-3 alkyl moieties, one or both of said C2-3 alkyl moieties may be substituted by a hydroxy group in the 2 or 3 position; and wherein, where R7 contains one or two C2-3 alkyl moieties, one or both of said C2-3 alkyl moieties may be substituted by a hydroxy group in the 2 or 3 position) and the acid addition salts thereof are disclosed. When R2 represents an N-formyl-piperazino group, these are valuable intermediate products for preparing the pteridines of formula I in which R2 represents a piperazino group, which have valuable pharmacological properties, more particularly antithrombotic and metastasis-inhibiting effects and an inhibiting activity on tumour growth.